Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
repeated dose toxicity: inhalation
Remarks:
other: not specified
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: According to the OECD SIDS document for sodium hydroxide (March 2002), a Klimisch 4 reliability score was assigned since the original reference is not available.

Data source

Reference
Reference Type:
publication
Title:
No title available
Author:
Dluhos et al.
Year:
1969
Bibliographic source:
cited in: Martin FM, Report EPA/600/8-88/081, Order-No. PB88-231949, 1988

Materials and methods

Principles of method if other than guideline:
other: not specified
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): sodium hydroxide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
10 weeks
Frequency of treatment:
20 min., twice weekly
Doses / concentrations
Remarks:
Doses / Concentrations:
40% (dispersed aerosol)
Basis:

Control animals:
other: no data specified
Details on study design:
Post-exposure period: not specified

Results and discussion

Results of examinations

Details on results:
Bronchial epithelium was sometimes wrinkeled, sometimes flattened and in places ulcerated and necrotic; the peribronchial lymphadenoid tissue was hypertrophic and extruded cushion-like into the bronchial lumen, causing slit-like deformities.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion