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EC number: 297-794-6 | CAS number: 93762-77-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1977-12-01
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restriction because although it is an acceptable and well documented study report a GLP statement was not provided and details regarding the test material and animal husbandry was not provided.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Noakes and Sanderson (1969)
- Principles of method if other than guideline:
- Groups of rats were used for each of three dose levels. The test material was placed into shorn dorso-lumbar skin and bandaged. Rats were deprived of food but allowed water ad libitum during the 24 hour exposure period.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Alkenes, C11-15
- IUPAC Name:
- Alkenes, C11-15
- Details on test material:
- - Name of test material (as cited in study report): Internal Olefin 114 LP11
- Test substance: Alkenes, C11-15
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Shell Toxicology Laboratory (Tunstall), Breeding Unit
- Age at study initiation: Approximately 12 to 13 weeks
- Weight at study initiation: Not reported
- Fasting period before study: No
- Housing: Housed individually during the 24 hour exposure period. After exposure rats were housed 4 of one sex in each cage
- Diet (e.g. ad libitum): Not reported
- Water (e.g. ad libitum): Not reported
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
Administration / exposure
- Type of coverage:
- other: percutaneous
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorso-lumbar skin
- % coverage: Not reported
- Type of wrap if used: Impermeable dressing of aluminium foil and water proof plaster.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Washed with tepid dilute detergent solution.
- Time after start of exposure: 24 hours
VEHICLE - The test substance was undiluted. - Duration of exposure:
- 24 hours
- Doses:
- 1.0 mL/kg, 2.0 mL/kg and 4.0 mL/kg
- No. of animals per sex per dose:
- Four animals per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 9 days
- Frequency of observations and weighing: Not reported
- Necropsy of survivors performed: No
- Other examinations performed: None
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 mL/kg bw
- Remarks on result:
- other: Equivalent to 3040 mg/kg
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- 2 - 4 mL/kg bw
- Remarks on result:
- other: Equivalent to 1520 to 3040 mg/kg
- Mortality:
- Three male rats died at the 4.0 ml/kg dose level. No deaths occurred at 1.0 or 2.0 ml/kg dose levels.
- Clinical signs:
- other: Rats showed no signs of toxic reactions.
- Gross pathology:
- Pathology data was provided.
- Other findings:
- - Organ weights: No data
- Histopathology: No data
- Potential target organs: No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Three males died at the 4.0 ml/kg dose level. This rats who died were noted to not eat or drink during the observation period, thus losing a considerable amount of body weight. No other deaths were reported. The acute percutaneous LD50 of Internal Olefin 114 LP11 in rats was greater than 4 ml/kg in females and between w and 4 ml/kg in males.
- Executive summary:
In an acute percutaneous toxicity study, groups of young Wistar rats, 4 male and 4 female, were dermally exposed to undiluted Internal Olefin 114 LP11 for 24 hours at doses of 1, 2, and 4 mL/kg bw. Animals then were observed for 9 days.
Three males died at the 4.0 mL/kg dose level. This rats who died were noted to not eat or drink thus losing a considerable amount of body weight. No other deaths were reported. The acute percutaneous LD50 of Internal Olefin 114 LP11 in rats was greater than 4 mL/kg (i.e., 3040 mg/kg) in females and between 2 and 4 mL/kg (i.e., 1520 to 3040 mg/kg) in males.
This study received a Klimisch score of 2 and is classified as reliable with restriction because although it is an acceptable and well documented study report a GLP statement was not provided and details regarding the test material and animal husbandry was not provided.This study will influence the DNEL(s).
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