Registration Dossier
Registration Dossier
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EC number: 202-488-2 | CAS number: 96-20-8
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The available evidence on degradation, bioaccumulation potential, and toxicity for 2-aminobutan-1-ol
(2-AB) indicates that the screening criteria for persistence (P), bioaccumulation potential (B), and
toxicity (T) are not met. Based on the information described below for the relevant endpoints, 2-AB is
considered as not PBT/vPvB.
Summary conclusion on PBT or vPvB properties
Constituent
P/vP
B/vB
T
2-aminobutan-1-ol
EC no. 202-488-2
CAS no. 96-20-8
Readily biodegradable
(The Dow Chemical
Company, 2010)
Conclusion: Not P/vP
based on screening
criteria.
Measured log Pow is
-0.45 at 20°C (Lhotak, H.,
1996)
Conclusion: Not B/vB
based on screening
criteria.
LC50/EC50 values96 hour=
270 mg/L forLeuciscus idus
melanotus(ANGUS
Chemical Company, 1991)
LC50/EC5048 hour= 115 mg/L
forDaphnia magna
(ANGUS Chemical
Company, 2009)
EC5096 hr.= 0.91 mg/L
Pseudokirchneriella
subcapitata (ANGUS
Chemical Company, 2009)
Conclusion: Not T based on
screening criteria
Impurity
P/vP
B/vB
T
2-(methylamino)butan-1-
ol
EC no. 248-591-6
CAS no. 27646-79-3
ca. 1.4% (w/w)
Based on structural
similarity to 2-
aminobutan-1-ol, this
substance can be
considered readily
biodegradable. BIOWIN
version 4.10 predicts rapid
biodegradation.
Conclusion: Not P/vP
based on screening
criteria.
Estimated log Pow is
–0.24 (KOWWIN version
1.67)
Conclusion: Not B/vB
based on screening
criteria.
Based on structural
similarity to 2-
(methylamino)butan-1-ol,
this substance is expected
to have ecotoxicity
endpoint values greater
than the toxicity threshold
for T. Predicted acute
toxicity LC50/EC50values
for fish, water fleas, and
algae range from 5 to 400
mg/L (ECOSAR version
1.00).
Conclusion: Not T based on
screening criteria.
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