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REACH

2-aminobutan-1-ol

EC number: 202-488-2 | CAS number: 96-20-8

Life Cycle description
Uses advised against

Classification & Labelling & PBT assessment

Administrative data

PBT assessment: overall result

PBT status:

the substance is not PBT / vPvB

Justification:

The available evidence on degradation, bioaccumulation potential, and toxicity for 2-aminobutan-1-ol

(2-AB) indicates that the screening criteria for persistence (P), bioaccumulation potential (B), and

toxicity (T) are not met. Based on the information described below for the relevant endpoints, 2-AB is

considered as not PBT/vPvB.

Summary conclusion on PBT or vPvB properties

Constituent	P/vP	B/vB	T
2-aminobutan-1-ol EC no. 202-488-2 CAS no. 96-20-8	Readily biodegradable (The Dow Chemical Company, 2010) Conclusion: Not P/vP based on screening criteria.	Measured log Pow is -0.45 at 20°C (Lhotak, H., 1996) Conclusion: Not B/vB based on screening criteria.	LC50/EC50 values96 hour= 270 mg/L forLeuciscus idus melanotus(ANGUS Chemical Company, 1991) LC50/EC5048 hour= 115 mg/L forDaphnia magna (ANGUS Chemical Company, 2009) EC5096 hr.= 0.91 mg/L Pseudokirchneriella subcapitata (ANGUS Chemical Company, 2009) Conclusion: Not T based on screening criteria
Impurity	P/vP	B/vB	T
2-(methylamino)butan-1- ol EC no. 248-591-6 CAS no. 27646-79-3 ca. 1.4% (w/w)	Based on structural similarity to 2- aminobutan-1-ol, this substance can be considered readily biodegradable. BIOWIN version 4.10 predicts rapid biodegradation. Conclusion: Not P/vP based on screening criteria.	Estimated log Pow is –0.24 (KOWWIN version 1.67) Conclusion: Not B/vB based on screening criteria.	Based on structural similarity to 2- (methylamino)butan-1-ol, this substance is expected to have ecotoxicity endpoint values greater than the toxicity threshold for T. Predicted acute toxicity LC50/EC50values for fish, water fleas, and algae range from 5 to 400 mg/L (ECOSAR version 1.00). Conclusion: Not T based on screening criteria.

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