Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute oral toxicity of 2-aminobutanol in the Rat

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
1 800 mg/kg bw

Additional information

The LD50 of DL 2 -aminobutanol in the rat is approximately 1800 mg/kg bw. There was no indication of the cause of death reported in the study.

There is no data available on the dermal and inhalation toxicity of 2 -aminobutanol. Due to the corrosivity of the substance this endpoint is waived according to the criteria in Column 2 of the REACH text, Annex VIII

Justification for classification or non-classification

Based on the Oral LD50 value, 2 -aminobutanol should be considered to be Harmful (R22) according to the dangerous substances directive, and Acute toxicity Category 4 according to GHS.

No classification for Dermal toxicity is proposed based on read across and the likelyhood that were such a test performed, the LD50 would be in excess of 2000 mg/kg bw.