Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
The target substance TOS is an oxime silane that undergoes rapid hydrolysis in aqueous to MEKO and the corresponding silanol. At the same time, silanols undergo continuous condensation reaction to produce higher molecular weight siloxanes which are in the molecular weight range large enough to be considered biologically unavailable. Therefore, the toxicity of TOS is due to the hydrolysis product MEKO and their values are comparable.
See attached reporting format.

Reason / purpose for cross-reference:
read-across source
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 106.9 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
(analogue substance)
Basis for effect:
mortality (fish)
Remarks on result:
other: (Based on read-across approach from an analogue)
Details on results:
Based on the experimental results obtained with the analogue substance butanone oxime (96h LC50 >100 mg/L ), the read-across approach is applied and the 96h LC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be 106.9 mg/L.
Validity criteria fulfilled:
not applicable
Conclusions:
Based on the read-across approach from experimental results on analogue butanone oxime, the 96h-LC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime in fish was determined to be >106.90 mg/L.
Executive summary:

A fish acute toxicity test was performed on analogue substance butanone oxime by the Japanese Ministry of the Environment according to OECD TG 203. The 96h-LC50 in fish (Oryzias lapides) was determined to be >100 mg/L. Based on these results, the read-across approach was performed and the 96-LC50 in fish for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be > 106.90 mg/L.

Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
The target substance TOS is an oxime silane that undergoes rapid hydrolysis in aqueous to MEKO and the corresponding silanol. At the same time, silanols undergo continuous condensation reaction to produce higher molecular weight siloxanes which are in the molecular weight range large enough to be considered biologically unavailable. Therefore, the toxicity of TOS is due to the hydrolysis product MEKO and their values are comparable.
See attached reporting format.

Reason / purpose for cross-reference:
read-across source
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
901.2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
(analogue substance)
Basis for effect:
mortality (fish)
Remarks on result:
other: (Based on read-across approach from an analogue)
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
901.2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
(analogue substance)
Basis for effect:
behaviour
Remarks on result:
other: (based on read-across approach from an analogue)
Details on results:
Based on the experimental results obtained with the analogue substance butanone oxime (96h LC50 =843 mg/L ), the read-across approach is applied and the 96h LC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be 901.2 mg/L.
Validity criteria fulfilled:
not applicable
Conclusions:
Based on the read-across approach from experimental results on analogue butanone oxime, the 96-LC50 in fish for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be 901.20 mg/L based on mortality.
Executive summary:

An acute toxicity test on Fathead Minnows (Pimephales promelas) was performed with the analogue substance butanone oxime in accordance with a method equivalent to OECD Guideline 203. 25 fish for tank and replicate (2 replicates per dose) were exposed for 96 hours to concentrations up to 1806 mg/L and the 96h-LC50 in fish was determined to be 843 mg/L (basis for effect: mortality). Based on these results, the read-across approach was performed and the 96-LC50 in fish for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be 901.20 mg/L.

Description of key information

Key study: Read-across from experimental data on analogue butanone oxime: The 96-LC50 in fish for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be 901.20 mg/L.

Key study: Read-across from experimental data on analogue butanone oxime: The 96h-LC50 in fish for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be >106.90 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
LC50
Effect concentration:
901.2 mg/L

Additional information

Read-across approach from analogue butanone oxime:

Key study: Based on the read-across approach from experimental data on analogue butanone oxime (test method equivalent to OECD 203, 96h-LC50 in Fathead Minnows (Pimephales promelas) = 843 mg/L based on mortality), the 96-LC50 in fish for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be 901.20 mg/L.

Key study: Based on the read-across approach from experimental data on analogue butanone oxime (test method according to OECD TG 203, 96h-LC50 in Oryzias lapides fish >100 mg/L), the 96h-LC50 in fish for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be >106.90 mg/L.