Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to Guideline study (non-GLP).

Data source

Reference
Reference Type:
publication
Title:
The comparative acute toxicity and primary irritancy of the monohexyl ethers of ethylene and diethylene glycol.
Author:
Ballantyne, B. & Myers, R.C.
Year:
1987
Bibliographic source:
Vet. Hum. Toxicol. 29, 361-366

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
no
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
2-(2-hexyloxyethoxy)ethanol
EC Number:
203-988-3
EC Name:
2-(2-hexyloxyethoxy)ethanol
Cas Number:
112-59-4
IUPAC Name:
2-[2-(hexyloxy)ethoxy]ethanol
Details on test material:
- Name of test material (as cited in study report): Diethylene glycol monohexyl ether
- Ethoxylation degree: 2
- Physical state: Colourless liquid
- Analytical purity: No data
- Lot/batch No.: No data
- Storage condition of test material: No data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
As described in guideline.

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
6 h
Concentrations:
Saturated vapour atmosphere (calculated)
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 100 mg/m³ air
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: Effect level represents calculated saturated vapour pressure.
Mortality:
No treatment-related effects.
Clinical signs:
other: No treatment-related effects.
Body weight:
No treatment-related effects.
Gross pathology:
No treatment-related effects.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU