Registration Dossier
Registration Dossier
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EC number: 500-201-8 | CAS number: 68213-23-0 1 - 2.5 moles ethoxylated
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to Guideline study (non-GLP).
Data source
Reference
- Reference Type:
- publication
- Title:
- The comparative acute toxicity and primary irritancy of the monohexyl ethers of ethylene and diethylene glycol.
- Author:
- Ballantyne, B. & Myers, R.C.
- Year:
- 1 987
- Bibliographic source:
- Vet. Hum. Toxicol. 29, 361-366
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(2-hexyloxyethoxy)ethanol
- EC Number:
- 203-988-3
- EC Name:
- 2-(2-hexyloxyethoxy)ethanol
- Cas Number:
- 112-59-4
- IUPAC Name:
- 2-[2-(hexyloxy)ethoxy]ethanol
- Details on test material:
- - Name of test material (as cited in study report): Diethylene glycol monohexyl ether
- Ethoxylation degree: 2
- Physical state: Colourless liquid
- Analytical purity: No data
- Lot/batch No.: No data
- Storage condition of test material: No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- As described in guideline.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 6 h
- Concentrations:
- Saturated vapour atmosphere (calculated)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 100 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: Effect level represents calculated saturated vapour pressure.
- Mortality:
- No treatment-related effects.
- Clinical signs:
- other: No treatment-related effects.
- Body weight:
- No treatment-related effects.
- Gross pathology:
- No treatment-related effects.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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