Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: publication
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature, no details

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1991
Reference Type:
publication
Title:
Unnamed
Year:
1991
Report Date:
1991

Materials and methods

Study type:
clinical case study
Endpoint addressed:
other: description of several clinical symptoms
Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Method

Type of population:
occupational
Subjects:
russian rubber workers
Ethical approval:
not applicable
Route of exposure:
inhalation
Reason of exposure:
unintentional, occupational
Exposure assessment:
measured
Details on exposure:
inhalation of mean concentrations ranging from 271 to 542 ppm
Examinations:
no data
Medical treatment:
no data

Results and discussion

Clinical signs:
-workers suffer from keratitis, rhinitis, headache, hypotonia, leukopenia, neutrophilia, lymphocytosis and impairment of pigment and carbohydrate metabolism
-relation between elevated cancer risk in rubber industrie and VCH exposure not clear

Applicant's summary and conclusion