Registration Dossier
Registration Dossier
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EC number: 254-179-7 | CAS number: 38888-98-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Available information:
1,1-DPE:
The respiration rate of an activated sludge exposed to 1,1-DPE and fed with a standard amount of synthetic sewage feed was measured.. The inhibitory effect of the test substance was expressed as a percentage of the mean respiration rates of two controls. For a respiration inhibition test to be considered valid, the control values should be within 30% of each other. An EC50 obtained for the reference material must be within 2-25 mg/L. The control coefficient variation was 24% and an EC50 value of 9.19 mgIL was determined for the reference substance, rendering the test valid. For test substance 1-Phenylethylbenzene, an EC50 of> 1 000 mg/L was obtained at 3 hours post dose. Results presented are based on nominal concentrations.
Phenyltolylethane:
The influence of Phenyl-tolyl-ethane on the respiration rate of activated sludge was investigated after a contact time of 3 hours according to OECD guideline 209. The EC50 was above the highest loading rate tested (1000 mg/l).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
Additional information
From the available data for toxicity to microorganism it can be concluded that 1,1’-DPE is devoid of any relevant toxicity to microorganisms.
This is confirmed by data from the read-across substance PTE which also demonstrates no relevant toxicity to microorganism (EC50 > 1000 mg/l).
The key study is GLP-compliant and has a Klimisch score of 1 (1,1 -DPE). The key study is used for chemical safety assessment. No further testing is required. For detailed read across rationale and justification see section 13, Read across document.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
