Registration Dossier
Registration Dossier
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EC number: 219-956-7 | CAS number: 2582-30-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline used simillar to the guideline of today.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US Department of Agriculture (Fed Reg 38, 187, 27019, 1973)
- GLP compliance:
- no
Test material
- Reference substance name:
- Aminoguanidinium hydrogen carbonate
- EC Number:
- 219-956-7
- EC Name:
- Aminoguanidinium hydrogen carbonate
- Cas Number:
- 2582-30-1
- Molecular formula:
- CH6N4.CH2O3
- IUPAC Name:
- carbamimidoyldiazanium hydrogen carbonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- content 99 %
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3-4 kg
- Housing: singly
- Diet ad libitum
- Water ad libitum
standard conditions
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: shorn: intact and scarificed
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the opposite site served as control
- Amount / concentration applied:
- no details given
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 4
- Details on study design:
- According to the US Department of Agriculture (Fed Reg. 38, 187, 27019, 1973).
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: avg 24, 48, 72 h
- Score:
- 0
- Remarks on result:
- other: intact or scarificed skin of rabbits
- Irritant / corrosive response data:
- No irritation effects were observed
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
Aminoguanidinium hydrogen carbonate was investigated for skin irritating property in rabbits using a guideline given by the U.S. Department of Agriculture (Fed. Reg 38, 187, 27019, 1973).
Aminoguanidinium hydrogen carbonate caused no irritation in the skin of rabbits.
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