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Administrative data

Workers - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

Workers: Other Gas Oils (Non-Carcinogenic)

  Effect Route DNEL Dose Descriptor Modified Dose Descriptor and Assessment Factors 
Acute Exposure Systemic Dermal (a)    
Inhalation 5000 mg/m3/ 15 min (for lethality) [aerosol] 1560 mg/m3/4 h (NOAEC based on lethality in acute inhalation study in rats) Dose descriptor was modified to correct starting point of 16,723 mg/m3/15 min by adjustment for duration of exposure and level of activity. Then a total AF of 7.5 was applied for inter- and intraspecies differences.
Local Dermal (a)    
Inhalation (a)    
Long-Term Exposure Systemic (b) Dermal 2.9 mg/kg/8h 30 mg/kg/day (NOAEL based on on increased liver and spleen weights, altered bone marrow function (decreased haematopoiesis, red blood cell count, haemoglobin, and haematocrit) and liver histopathology in rats) Dose descriptor was modified to correct starting point of 58.1 mg/kg/day by adjustment for dermal absorption.. Then a total AF of 24 was applied for subchronic to chronic and inter- and intraspecies differences.
Inhalation 16 mg aerosol /m3/8h [aerosol] 30 mg/kg/day (NOEL based on increased resorption, incomplete skeletal ossification, decreased foetal weights and decreased litter size in a dermal developmental toxicity study in rats with dosing on GD 0-19) Dose descriptor was modified to correct starting point of 205.1 mg/m3/8 h by adjustment for dermal absorption, extrapolation from dermal to inhalation route, and ventilation in workers. Then a total AF of 7.5 was applied for inter- and intraspecies and remaining differences.
Local Dermal (a) for 13-wk exposures and    
(c) for chronic exposures (dermal carcinogen)
Inhalation (a)    

a) No hazard identified for this route (data available)

b) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.

c) No-threshold effect and/or no dose-response information available

Worker: Carcinogenic or Unknown Other Gas Oils

 

Effect

Route

DNEL

Dose Descriptor

Modified Dose Descriptor and Assessment Factors

Acute Exposure

Systemic

Dermal

(a)

 

 

Inhalation

5000 mg/m3/ 15 min (for lethality) [aerosol]

1560 mg/m3/4 h (NOAEC based on lethality in acute inhalation study in rats)

Dose descriptor was modified to correct starting point of 16,723 mg/m3/15 min by adjustment for duration of exposure and level of activity. Then a total AF of 7.5 was applied for inter- and intraspecies differences.

Local

Dermal

(a)

 

 

Inhalation

(a)

 

 

Long-Term Exposure

Systemic (b)

Dermal

2.9 mg/kg/8h

30 mg/kg/day

 (NOAEL based onon increased liver and spleen weights, altered bone marrow function (decreased haematopoiesis, red blood cell count, haemoglobin, and haematocrit) and liver histopathologyin rats)

Dose descriptor was modified to correct starting point of 58.1 mg/kg/day by adjustment for dermal absorption.. Then a total AF of 24 was applied for subchronic to chronic and inter- and intraspecies differences.

Inhalation

16 mg aerosol /m3/8h [aerosol]

30 mg/kg/day

 (NOEL basedon increased resorption, incomplete skeletal ossification, decreased foetal weights and decreased litter sizein a dermal developmental toxicity study in rats with dosing on GD 0-19)

 

Dose descriptor was modified to correct starting point of 205.1 mg/m3/8 h by adjustment for dermal absorption, extrapolation from dermal to inhalation route, and ventilation in workers. Then a total AF of 7.5 was applied for inter- and intraspecies and remaining differences.

Local

Dermal

(a) for 13-wk exposures and

(c) for chronic exposures (dermal carcinogen)

 

 

Inhalation

(a)

 

 

a) No hazard identified for this route (data available)

b) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.

c) No-threshold effect and/or no dose-response information available

General Population - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard via oral route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

General Population Other Gas Oils

 

 

 

Effect

Route

DNEL

Dose Descriptor

Modified Dose Descriptor and Assessment Factors

Acute Exposure

Systemic

Dermal

(a)

 

 

Inhalation

3000 mg/m3/ 15 min (for lethality) [aerosol]

1560 mg/m3/4 h (NOAEC based on lethality in acute inhalation study in rats)

Dose descriptor was modified to correct starting point of 16,723 mg/m3/15 min by adjustment for duration of exposure and level of activity. Then a total AF of 7.5 was applied for inter- and intraspecies differences.

Local

Dermal

(a)

 

 

Inhalation

(a)

 

 

Long-Term Exposure

Systemic (b)

Dermal

1.3 mg/kg/8h

30 mg/kg/day

 (NOAEL based onon increased liver and spleen weights, altered bone marrow function (decreased haematopoiesis, red blood cell count, haemoglobin, and haematocrit) and liver histopathologyin rats)

Dose descriptor was modified to correct starting point of 58.1 mg/kg/day by adjustment for dermal absorption.. Then a total AF of 24 was applied for subchronic to chronic and inter- and intraspecies differences.

Inhalation

4.8 mg aerosol /m3/8h [aerosol]

30 mg/kg/day

 (NOEL basedon increased resorption, incomplete skeletal ossification, decreased foetal weights and decreased litter sizein a dermal developmental toxicity study in rats with dosing on GD 0-19)

 

Dose descriptor was modified to correct starting point of 205.1 mg/m3/8 h by adjustment for dermal absorption, extrapolation from dermal to inhalation route, and ventilation in workers. Then a total AF of 7.5 was applied for inter- and intraspecies and remaining differences.

Local

Dermal

(a) for 13-wk exposures and

(c) for chronic exposures (dermal carcinogen)

 

 

Inhalation

(a)

 

 

a) No hazard identified for this route (data available)

b) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.

c) No-threshold effect and/or no dose-response information available

General Population Carcinogenic or Unknown Other Gas Oils

 

 

Effect

Route

DNEL

Dose Descriptor

Modified Dose Descriptor and Assessment Factors

Acute Exposure

Systemic

 

Dermal

(a)

 

 

Inhalation

(a)

 

 

Local

Dermal

(a)

 

 

Inhalation

(a)

 

 

Long-Term Exposure

Systemic (b)

Dermal

(a)

 

 

Inhalation

(a)

 

 

Oral

1.3 mg/kg/24h

30 mg/kg/day

 (NOAEL based onon increased liver and spleen weights, altered bone marrow function (decreased haematopoiesis, red blood cell count, haemoglobin, and haematocrit) and liver histopathologyin rats)

 

Dose descriptor was modified to correct starting point of 41.5 mg/kg/24 h by adjustments for dermal absorption, dermal to oral route, and duration and frequency of daily dosing. Then AF of 40 was applied for inter- and intraspecies differences and for total duration.

Local

Dermal

(a)

 

 

Inhalation

(a)

 

 

a) No DNEL needed since no exposure expected

b) Long-term systemic effects include developmental/reproductive effects. Lowest DNEL is shown.