Registration Dossier
Registration Dossier
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EC number: 911-694-8 | CAS number: -
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1959
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: published communication not detailling the used method
Data source
Reference
- Reference Type:
- publication
- Title:
- A note on glycerol formal as a solvent in toxicity testing
- Author:
- Sanderson DM
- Year:
- 1 959
- Bibliographic source:
- J. Pharm. Pharmacol., 11: 150-156
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A group of four female rat was given 1000 mg/kg subcutaneously.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Glycerol formal
- IUPAC Name:
- Glycerol formal
- Details on test material:
- Not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1000 mg/kg
- No. of animals per sex per dose:
- 4
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Conclusions:
- Rats treated with 1000 mg/kg subcutaneously were completely unaffected, and showed no evidence of local irritation at the injection site. DL50 is >1000 mg/kg.
- Executive summary:
A group of four female rats was given 1000 mg/kg subcutaneously. They were completely unaffected, and showed no evidence of local
irritation at the injection site. DL50 is >1000 mg/kg.
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