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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1959
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: published communication not detailling the used method

Data source

Reference
Reference Type:
publication
Title:
A note on glycerol formal as a solvent in toxicity testing
Author:
Sanderson DM
Year:
1959
Bibliographic source:
J. Pharm. Pharmacol., 11: 150-156

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A group of four female rat was given 1000 mg/kg subcutaneously.
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Glycerol formal
IUPAC Name:
Glycerol formal
Details on test material:
Not specified

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
unchanged (no vehicle)
Doses:
1000 mg/kg
No. of animals per sex per dose:
4
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 1 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Conclusions:
Rats treated with 1000 mg/kg subcutaneously were completely unaffected, and showed no evidence of local irritation at the injection site. DL50 is >1000 mg/kg.
Executive summary:

A group of four female rats was given 1000 mg/kg subcutaneously. They were completely unaffected, and showed no evidence of local

irritation at the injection site. DL50 is >1000 mg/kg.