Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 911-694-8 | CAS number: -
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1959
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: published communication not detailling the used method
Data source
Reference
- Reference Type:
- publication
- Title:
- A note on glycerol formal as a solvent in toxicity testing
- Author:
- Sanderson DM
- Year:
- 1 959
- Bibliographic source:
- J. Pharm. Pharmacol., 11: 150-156
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A group of four female rat was given 1000 mg/kg subcutaneously.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Glycerol formal
- IUPAC Name:
- Glycerol formal
- Details on test material:
- Not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1000 mg/kg
- No. of animals per sex per dose:
- 4
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Conclusions:
- Rats treated with 1000 mg/kg subcutaneously were completely unaffected, and showed no evidence of local irritation at the injection site. DL50 is >1000 mg/kg.
- Executive summary:
A group of four female rats was given 1000 mg/kg subcutaneously. They were completely unaffected, and showed no evidence of local
irritation at the injection site. DL50 is >1000 mg/kg.
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