Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Remarks:
combined repeated dose and reproduction / developmental screening
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guideline
Guideline:
OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenyl-2-imidazoline
EC Number:
213-313-4
EC Name:
2-phenyl-2-imidazoline
Cas Number:
936-49-2
Molecular formula:
C9H10N2
IUPAC Name:
2-phenyl-4,5-dihydro-1H-imidazole

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Duration of treatment / exposure:
45d

Results and discussion

Effect levels

Dose descriptor:
NOEL
Effect level:
204 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: 45d test; rat, oral, gavage OECD TG422 protocol

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

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