2-phenyl-2-imidazoline

Repeated dose toxicity: oral

Administrative data

Endpoint:

short-term repeated dose toxicity: oral

Remarks:

combined repeated dose and reproduction / developmental screening

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Test guideline

Guideline:

OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-phenyl-2-imidazoline

EC Number:

213-313-4

EC Name:

2-phenyl-2-imidazoline

Cas Number:

936-49-2

Molecular formula:

C9H10N2

IUPAC Name:

2-phenyl-4,5-dihydro-1H-imidazole

Test animals

Species:

rat

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Duration of treatment / exposure:

45d

Results and discussion

Effect levels

Dose descriptor:

NOEL

Effect level:

204 mg/kg bw/day (nominal)

Based on:

test mat.

Sex:

male/female

Basis for effect level:

other: 45d test; rat, oral, gavage OECD TG422 protocol

Target system / organ toxicity

Critical effects observed:

not specified