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EC number: 213-313-4 | CAS number: 936-49-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- No information
- Author:
- Anonymous
- Year:
- 2 007
- Bibliographic source:
- IUCLID4 data set, 2007
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-phenyl-2-imidazoline
- EC Number:
- 213-313-4
- EC Name:
- 2-phenyl-2-imidazoline
- Cas Number:
- 936-49-2
- Molecular formula:
- C9H10N2
- IUPAC Name:
- 2-phenyl-4,5-dihydro-1H-imidazole
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- Phenobarbital / beta-naphthoflavone co-induced rat liver S9 fraction
- Test concentrations with justification for top dose:
- 50 to 5000 Ug/plate
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- GENOTOXIC EFFECTS:
- With metabolic activation: None
- Without metabolic activation: None
The positive controls were functional in the finally evaluated tests.
PRECIPITATION CONCENTRATION: Precipitation was not observed.
CYTOTOXIC CONCENTRATION (including effects on background lawn):
TA 98: 5000 Ug/plate (+ S9), 1500 Ug/plate (- S9)
TA 100: none (+ S9), 2000 Ug/plate (- S9)
TA 1535: 5000 Ug/plate (+ S9), >= 2000 Ug/plate (- S9)
TA 1537: 5000 Ug/plate (+ S9), 2000 Ug/plate (- S9) - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
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