Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-433-6 | CAS number: 27375-52-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- human
- Type of coverage:
- other: semiocclusive and occlusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 0.926
- Reversibility:
- no data
- Remarks on result:
- other: not irritating to the skin of human
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- By primary dermal irritation index (PDII) from QSAR , skin irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide estimated as 0.926 based on this score it is indicated that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the skin of human.
- Executive summary:
By primary dermal irritation index (PDII) from QSAR , skin irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide estimated as 0.926 based on this score it is indicated that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the skin of human.
Reference
The prediction was based on dataset comprised from the following descriptors: "Primary Irritation Index"
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and "b" ) and ("c" and "d" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=60%,
Dice(Atom pairs)
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= -1.54
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.735
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 1-30 percent
- Duration of treatment / exposure:
- 1-3 days
- Number of animals or in vitro replicates:
- 3-6
- Irritation parameter:
- other: MMAS(modified maximum average score (MMAS))
- Basis:
- mean
- Score:
- 22.2
- Reversibility:
- not specified
- Remarks on result:
- other: not irritating to eye
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The modified maximum average score (MMAS) from QSAR eye irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is estimated as 22.2. This score indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
- Executive summary:
The modified maximum average score (MMAS) from QSAR eye irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is estimated as 22.2. This score indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
Reference
The prediction was based on dataset comprised from the following descriptors: MMAS
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= -0.843
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 1.53
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
By primary dermal irritation index (PDII) from QSAR , skin irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide estimated as 0.926 based on this score it is indicated that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the skin of human.
Eye irritation
The modified maximum average score (MMAS) from QSAR eye irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is estimated as 22.2. This score indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
Justification for selection of skin irritation / corrosion endpoint:
By primary dermal irritation index (PDII) from QSAR , skin irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide estimated as 0.926 based on this score it is indicated that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the skin of human.
Justification for selection of eye irritation endpoint:
The modified maximum average score (MMAS) from QSAR eye irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is estimated as 22.2. This score indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
Justification for classification or non-classification
The available studies indicate that N-[4-[(2-hydroxyethyl) sulphonyl]phenyl] acetamide is not classified as a skin and eye irritant, according to CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
