Registration Dossier
Registration Dossier
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EC number: 261-448-2 | CAS number: 58798-47-3
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- no DNEL required: short term exposure controlled by conditions for long-term
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
Basic Yellow 28 acetate is only stable in presence of significant concentrations of free acetic acid; it cannot be isolated as such. The test substance is an aqueous solution in 40 % acetic acid. The acetic acid solution has the more relevant vapour pressure with 20.79 hPa at 25 ˚C than Basic Yellow 28 acetate. The vapour pressure of Basic Yellow 28 methyl sulfate is 3.3E-7 hPa at 25 °C; hence only the acetic acid is inhalable.
The toxicity of this substance is triggered by the amount of acetic acid contained to stabilise the substance in the solution and its irritating effect. The 25 % acetic acid contained in the test substance relates to a 40 % acetic acid. As this solution is skin and eye irritating, exposure to the substance should be avoided.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The general population does not have access to Basic Yellow 28 Acetate. The textiles are dyed with Basic Yellow 28 at 96 to 120 °C at pH 3 to 4.5. After the dyeing process, the fabrics are cleaned with an alkaline reducing agent to remove the non-fixated portion of the dye and precipitate this portion as the Carbinol base (CAS No 81241-99-8; (2S)-2-{(E)-[2-(4-methoxyphenyl)-2-methylhydrazinylidene]methyl}-1,3,3-trimethyl-2,3-dihydro-1H-indol-2-ol). The fixation rate of the dye is 99 %, the typical concentration of the dye on the fabric is 3 %. Due to the strong ionic bound of the dye with the fabric, the dye has a very good fastness and migration or evaporation of the dye from the fabric to the customer is not likely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
