Registration Dossier
Registration Dossier
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EC number: 219-292-8 | CAS number: 2403-89-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- other: read across from 2,2,6,6 -tetramethylpiperidin-4 -ol (the analogue substance with no methyl group on N)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- See the summary of this endpoint
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- OECD SIDS 2,2’,6,6’-TETRAMETHYLPIPERIDIN-4-OL
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- OECD SIDS 2,2,6,6-Tetramethylpiperidin-4-ol (CAS 2403-88-5)
- Report date:
- 2002
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- other: read across
- Justification for non-LLNA method:
- Available (older) study
Test material
- Reference substance name:
- 2,2,6,6-tetramethylpiperidin-4-ol
- EC Number:
- 219-291-2
- EC Name:
- 2,2,6,6-tetramethylpiperidin-4-ol
- Cas Number:
- 2403-88-5
- Molecular formula:
- C9H19NO
- IUPAC Name:
- 2,2,6,6-tetramethylpiperidin-4-ol
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: skin sensitisation score
- Group:
- test chemical
- Dose level:
- 0
- No. with + reactions:
- 0
- Total no. in group:
- 0
- Clinical observations:
- This substance is classified as a moderate to strong sensitizer in albino guinea pigs according to the grading of Magunusson and Kligman.
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
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