1,2,2,6,6-pentamethylpiperidin-4-ol

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Type of information:

other: OECD Toolbox v3.4 read across study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Report date:

2019

Materials and methods

Test guideline

Guideline:

OECD Guideline 471 (Bacterial Reverse Mutation Assay)

GLP compliance:

not specified

Type of assay:

bacterial reverse mutation assay

Test material

Test material information

Constituent 1

Reference substance name:

1,2,2,6,6-pentamethylpiperidin-4-ol

EC Number:

219-292-8

EC Name:

1,2,2,6,6-pentamethylpiperidin-4-ol

Cas Number:

2403-89-6

Molecular formula:

C10H21NO

IUPAC Name:

1,2,2,6,6-pentamethylpiperidin-4-ol

Method

Species / strain

Species / strain / cell type:

S. typhimurium TA 1535, TA 1537, TA 98 and TA 100

Metabolic activation:

with and without

Metabolic activation system:

S9

Results and discussion

Test results

Test results 1

Species / strain:

S. typhimurium TA 1535, TA 1537, TA 98 and TA 100

Metabolic activation:

with

Genotoxicity:

positive

Cytotoxicity / choice of top concentrations:

not determined

Test results 2

Species / strain:

other: S. typhimurium TA 1535, TA 1537, TA 98, and TA 100

Metabolic activation:

without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

not determined

Remarks on result:

ambiguous mutagenic potential (based on QSAR/QSPR prediction)