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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guidelinestudy under GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chloro-α,α,α-trifluoro-o-toluidine
EC Number:
207-151-3
EC Name:
4-chloro-α,α,α-trifluoro-o-toluidine
Cas Number:
445-03-4
Molecular formula:
C7H5ClF3N
IUPAC Name:
4-chloro-α,α,α-trifluoro-o-toluidine

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: oleum sesami
Doses:
Female: 1250, 1600, 1800, 2000, 2250 mg/kg
Male: 1600, 2000, 2250 mg/kg
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
1 900 mg/kg bw
Based on:
not specified
Sex:
male
Dose descriptor:
LD50
Effect level:
1 980 mg/kg bw
Based on:
not specified
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 940 mg/kg bw
Based on:
not specified

Applicant's summary and conclusion

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