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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study generated according to valid and internationally accepted standard testing guidelines.
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Water solubility:
>= 21 - <= 24 mg/L
Temp.:
30 °C
pH:
>= 5.6 - < 8
Remarks on result:
other: the decrease of the pH solution after 24 h (from pH=8 to pH=5.6) is a strong indicator of the unstability of the substance
Details on results:
Because of the unstability of the tested substance after 24h, the water solubility study has been conducted on the 24h solution.
Using the flask method, the water solubility of the tested substance is 21 mg/l

Stability study :

The stability study of the tested substance in water is exposed in the 5.1 endpoint (hydrolysis). The study indicates that the substance degrades in a significant way beyond 24 hours, the solution becoming clouded. This degradation is certainly due to the formation of phosphorous acid by-products which can explain the reduction of the pH over time. The substance is stable during 24h in water under stirring with a concentration of 100mg/100ml. Thus, the water solubility study has to be conducted on the 24h solution.

Solubility Study :

The preliminary assays show that the solubility of the tested substance is < 1g/L.

reference solution :

 

Sample
(g)

Conc
(g/l)

Area

Area / conc

sol 1

0,1051

0,000186868

142069

760264743

sol 2

0,1045

0,000186868

138814

742846012

 

average

751555377,7

 

standard deviation

1231690,3

 

repeatability %

1,6

Samples solutions :

16 hours - in water

solution under stirring (Sa)

injected solutions

 

sample
(g)

water
(g)

conc
(g/g)

p Sa

p thf

Conc
 (g/l)

aera

aera / conc

 

0,988

97,324

0,0100496

10,2065

10 ml

9,118617827

171556

18814

 

1,0095

98,6173

0,0101328

10,0565

10 ml

9,058968742

178124

19663

 

1,0004

98,9307

0,0100109

9,9581

10 ml

8,862398193

138814

15663

 

average

18046,6

 

standard deviation

2107,2

 

repeatability %

11,7

 

24 hours - in water

Solution sunder stirring (Sa)

injected solutions

 

sample
(g)

water
(g)

conc
(g/g)

p Sa

p thf

conc
(g/l)

area

area / conc

 

0,987

97,7519

0,0099961

10,0633

10 ml

8,942749151

122496

13698

 

1,0078

98,6402

0,0101136

10,1530

10 ml

9,128552437

130815

14330

 

1,0226

98,4267

0,0102826

10,1703

10 ml

9,296930461

168995

18178

 

average

15402

 

standard deviation

2424,5

 

repeatabilty %

15,7

 

average after 24h

15401.9

average after 16h

18046.6

repeatability %

11.2

The repeatability (%) is quite lower than 15 % between the 16h- and 24h-assays.

The content in Phosphorous acid, triC12 -C14 alkyl esters is obtained by external calibration on the 16h- and 24h-solutions :

 

Area/conc

ppm

average of the 24h-solutions

15401.9

21

average of the 16h-solutions

18046.6

24

reference solution

751555377,7

1000000

The content detected by chromatography analyzer on the 24h-solutions in water is 21 mg/L

Thus, we can assume that the water solubility of the tested substance is 21 mg/L

The phosphorous acid, triC12 -C14 alkyl esters is stable 24h in water at a concentration of 100 mg/10 ml.

Conclusions:
Interpretation of results: slightly soluble (0.1-100 mg/L)
With the flask method, the solubility of the phosphorous acid, triC12 -C14 alkyl esters was 21 mg/L.
Executive summary:

The water solubility of the phosphorous acid, triC12-C14 alkylesters was investigated in a GLP-compliant study performed in accordance with EC A.6 method and OECD Guideline No. 105, using Flask method.

The solubility of the phosphorous acid, triC12 -C14 alkyl esters was 21 mg/L.

The phosphorous acid, triC12 -C14 alkyl esters is stable 24h in water at a concentration of 100 mg/10 ml.

Description of key information

The water solubility of the phosphorous acid, triC12-C14 alkyl esters was investigated in a GLP-compliant study performed in accordance with EC A.6 method and OECD Guideline No. 105, using Flask method.

The solubility of the phosphorous acid, triC12 -C14 alkyl esters was 21 mg/L.

The phosphorous acid, triC12 -C14 alkyl esters is stable 24h in water at a concentration of 100 mg/10 ml.

Key value for chemical safety assessment

Water solubility:
21 mg/L
at the temperature of:
30 °C

Additional information

The water solubility of the phosphorous acid, triC12-C14 alkylesters was investigated in one GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint.