Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 609-335-2 | CAS number: 3717-40-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Read across to CAS 665-66-7: Acute oral toxicity: LD50 (male/female): 890 - 1275 mg/kg bw; non-Guideline Study, Vernier et al., 1969.
The test substance is of moderate toxicity after single ingestion.
Key value for chemical safety assessment
Additional information
There are no valid in vivo data available for the assessment of the acute oral toxicity of the test item. Therefore data from a read across substance with similar structure (CAS 665 -66 -7) was used for assessment of the acute oral toxicity.
Acute Oral Toxicity
In the key study, a non-GLP and non-Guideline study, male and female rats (Carworth Farms CFE), (range of weight: 87 to 117 g (females); 113 to 141 g (males), (10/sex/dose) were given a single oral dose (unspecified) of the read across substance (CAS 665 -66 -7) (analytical purity unknown) at unknown dosages (Vernier et al., 1969). The test item was diluted in water (40% w/v) and administered at a maximum dose volume of 10 mL/kg bw. The animals were observed subsequently for a period of 7 to 14 days. There are no data available about gross pathology.
There are no data vailable for single animals about point in time of mortality. All deaths observed occured 30 min to 24 hours after oral doses.
Clinical signs were central nervous system stimulation followed by tremors and brief clonic convulsions. Death was preceded by signs of respiratory distress and convulsions. No data about body weight gain were specified.Conclusion: Under the conditions of the study the acute oral median lethal dose (LD50) of the read across substance (CAS 665 -66 -7) was found to be
890 mg/kg bw (761 - 1019 mg/kg bw) for female and
1275 mg/kg bw (1095 - 1455 mg/kg bw) for male rats.
Acute Dermal Toxicity
There are no data available. Due to the corrosivity of the test substance an acute dermal study is scientifically unjustified.
Acute Inhalation Toxicity
There are no data available. Due to the corrosivity of the test substance an acute inhalation study is scientifically unjustified.
Justification for classification or non-classification
Dangerous substance Directive (67/548/EEC)
The available experimental test data for acute oral toxicity are reliable and suitable for the purpose of classification under Directive 67/548/EEC. As a result the substance is considered to be classified for acute oral toxicity (R22, Harmful if swallowed) under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data for acute oral toxicity are reliable and suitable for the purpose of classification under EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008. As a result the substance is considered to be classified for acute oral toxicity (Cat 4, H302: Harmful if swallowed) under Regulation (EC) No.1272/2008, as amended for the 2nd time in Directive EC 286/2011.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
