Registration Dossier

Administrative data

Description of key information

A mean erythema score of 2.2 was determined in the key skin irritation study for 1-nonanol (read across) in rabbit (Jacobs & Martens 1992; rel 2). The key study for eye irritation is read across from 1-decanol (Eurofins 2008; rel 1), which finds the test substance to be an eye irritant based on corneal opacity readings of 1, iritis readings of  2 and conjunctival redness and chemosis scores of ≥2 in all animals.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

The 4 hour occlusive application to rabbit skin of undiluted 1-nonanol resulted in mean scores of ≥2, persistent throughout the 72 hour observation period (Jacobs & Martens 1992; rel 2). A reliability 2 study read across from 1 -decanol (Kaestner 1977) is included as support for the lack of effects in man.


Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

Despite the read across key finding which suggests that 1 -nonanol is irritating to rabbit skin, information across category in man which finds the linear alcohols not irritating to skin in humans is used as basis for no proposal for classification. The read across from 1-decanol for eye irritation classifies nonanol, branched and linear as a category 2 irritant to eye in accordance with CLP (EC regulation 1272/2008).