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EC number: 614-557-8 | CAS number: 68515-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Reproduction: The conclusion that the members of the aliphatic alcohol category (C6 to C22) are not expected to impair fertility is based on a weight of evidence approach using data from reproductive screening studies [C12 (dodecanol), C18 (octadecanol)],a fertility study [C22 (docosanol)], together with a lack of effect on the
reproductive organs in repeat dose studies over the range of linear and essentially linear alcohols. Based on this it is concluded that nonanol, branched and linear is not expected to impair fertility.
Chronic and sub-chronic toxicity studies have shown that long chain alcohols (LCA) are of low toxicity. Furthermore, combined repeated-dose studies with developmental endpoints, as well as reproductive and developmental studies showed no effects at the highest dose tested.
Rather than having separate values for the three endpoints, one endpoint “systemic effects” has been used instead. Since the NOAELs do not vary greatly across the category, one key study has been chosen as being representative of the whole category.
C6, Hexanol has been chosen as the category representative because shorter chain molecules are usually regarded as more toxic when compared to structural analogues with longer carbon chain lengths.
Short description of key information:
Two read across feeding studies reported a lack of effects on the reproductive organs of rats receiving 1 -hexanol (NOAEL 1127 mg/kg) (Scientific Associates Inc., 1966, rel; 2) and 1 -dodecanol (NOAEL 2000 mg/kg) (Hansen 1992, rel; 2 ). A read across from octan-1-ol is designated the key study for developmental toxicity reporting a NOAEL of 1300 mg/kg bw/day (Hellwig, 1997; rel 2).
Effects on developmental toxicity
Description of key information
A reliable developmental toxicity key study in rats by whole body inhalation exposure to 1 –nonanol over 19 days, reported a developmental and maternal NOAEC > 0.15mg/l, which was the highest dose tested. (Nelson et al, 1990).
In a reliable inhalation study (Nelson et al, 1990), the NOAEC for maternal toxicity, foetotoxicity and teratogenicity in rats following inhalation exposure to 1-nonanol during gestation days 1-19 was > 0.15 mg/l (the highest attainable concentration).
Additional information
Developmental effects: Based on the read across from octan-1 -ol and weight of evidence from other alcohols across the category, it is concluded that nonanol, branched and linear is unlikely to be a developmental toxicant in the absence of maternal toxicity.
Justification for classification or non-classification
Based upon the above information, nonanol branched and linear is not required to be classified in accordance with EU guidelines.
Additional information
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