Registration Dossier
Registration Dossier
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EC number: 919-274-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The following information is available for the irritation/corrosion endpoints:
Rodabaugh D.D. (2008c) A dermal corrosivity study in rats with with AS305BD. Testing laboratory: Charles River Laboratories, Preclinical Services. Report no.: LMT00080. Owner company: Chevron. Report date: 2008-02-13.
Rodabaugh D.D. (2008d) An acute irritation study of AS305BD administered by the ocular route to rabbits. Testing laboratory: Charles River Laboratories, Preclinical Services. Report no.: LMT00092. Owner company: Chevron. Report date: 2008-02-12.
These studies have been rated as 1 under the Klimisch scoring system and so are considered to be sufficient to address these endpoints.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In vivo animal studies have been performed to evaluate the irritating/corrosiveness of the substance. Results obtained in the primary skin irritation study showed that the substance causes severe irritation following application for 3 minutes, 1 hour or 4 hours. Although there were no microscopic indications of full thickness tissue destruction, erythema and oedema persisted in all test sites exposed for 1 or 4 hours up to the conclusion of the study on day 21. In addition, blanching and desquamation were also observed in all animals up to day 10, with desquamation still observable in a single animal exposed for 4 hours at the end of the study. Similarly, in the primary eye irritation study, performed using two animals, lesions involved the conjunctiva, iris and cornea; corneal opacity did not resolve at the end of the study on day 28 in one of the animals.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: irritating
Justification for classification or non-classification
The substance is considered to be corrosive to the skin and severely irritating to the eyes and has to be labelled with R34 – causes burns and R41 - risk of serious damage to eyes.
According to the GHS, the substance is assigned to Category 1C (H314) for skin corrosiveness and to Category 1 (H318) for eye irritation and requires signal of danger.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
