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EC number: 939-485-7 | CAS number: 218141-16-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Article of limited reporting; in French
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
Available data from Lauryloxypropylamine (Etheramine C12) are considered to be applicable for Etheramine C10i as well. The structure of Etheramine C12 only differs from that of Etheramine C10i, in that the alkyl chain is only 2 carbons longer. This only has limited effects on physical properties, whereas chemical behaviour, reactivity and metabolism are the same.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test material
- Reference substance name:
- Lauryloxypropylamine
- IUPAC Name:
- Lauryloxypropylamine
- Reference substance name:
- 34630-52-9
- Cas Number:
- 34630-52-9
- IUPAC Name:
- 34630-52-9
Constituent 1
Constituent 2
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Etheramine C12 is in rabbits rapidly distributed and quickly excreted mainly via urine with T1/2 of about half an hour. The data also suggest a quick metabolization.
- Executive summary:
SUMMARY. - Lauryloxypropylamine dosage in blood and urines is carried out by fluorimetry after HPLC separation, with dodecylamine as internal standard. Standard curve is linear till lauryloxypropylamine injection of 200 ng. Detection limit is of nearly 5 ng/injection. Lauryloxypropylamine pharmacokinetic study was carried out on rabbits with rapid intravenous administration of a 5 mg/kg dose. Different experimental curves obtained after blood and urine sampling and mathematic analysis allow to describe lauryloxypropylamine behaviour through the organism following an open pharmacokinetic model with two distribution compartments. Elimination half-life calculated time is of 29 mn and distribution volume of 13.37 I/kg.
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