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EC number: 939-485-7 | CAS number: -
The corneas were turbid after the 10 minutes of treatment with 3-(Isotridecyloxy)-1-propane amine
This report describes the ocular irritation properties of 3-(lsotridecyloxy)-1-propane amine on an isolated bovine cornea. The possible ocular irritancy of 3-(lsotridecyloxy)-1-propane amine was tested through topical application for 10±1 minutes. The study procedures described in this report were based on the most recent OECD guideline.
3-(lsotridecyloxy)-1-propane amine was a clear colourless liquid with a purity of 95.8%m/m(NMR). The test substance was applied as it is (750 µL) directly on top of the corneas.
The negative control responses of the opacity and permeability values were less than the upper limits of the laboratory historical range indicating that the negative control did not induce irritancy on the corneas. The mean in vitro irritancy score of the positive control (10%(w/v) Benzalkonium Chloride) was 138 and was within the historical positive control data range. It was therefore concluded that the test conditions were adequate and that the test system functioned properly.
3-(lsotridecyloxy)-1-propane amine induced severe ocular irritation through both endpoints, resulting in a meanin vitroirritancy score of 82 after 10 minutes of treatment.
Since 3-(lsotridecyloxy)-1-propane amine induced an IVIS ≥ 55.1, it is concluded that 3-(lsotridecyloxy)-1-propane amine is corrosive or severe irritant in the Bovine Corneal Opacity and Permeability test under the experimental conditions described in this report.
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