Registration Dossier

Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1991-07-24 to 1991-09-20
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Although no exhaustive description of the procedure is provided, the study is guideline-conform and it was conducted under GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrachloro-1,2-difluoroethane
EC Number:
200-935-6
EC Name:
Tetrachloro-1,2-difluoroethane
Cas Number:
76-12-0
Molecular formula:
C2Cl4F2
IUPAC Name:
1,1,2,2-tetrachloro-1,2-difluoroethane
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): 1,1,2,2-tetrachloro-1,2-difluoroethane
- Analytical purity: 89.7%

Radiolabelling:
no

Test solutions

Vehicle:
yes

Test organisms

Test organisms (species):
Cyprinus carpio

Study design

Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
6 wk

Results and discussion

Bioaccumulation factoropen allclose all
Type:
BCF
Value:
> 36 - < 106 dimensionless
Remarks on result:
other: Conc.in environment / dose:50 microg/L
Type:
BCF
Value:
> 29 - < 90 dimensionless
Remarks on result:
other: Conc.in environment / dose:5 microg/L

Applicant's summary and conclusion

Conclusions:
According to the source, the BCF of 1,1,2,2 -tetrachloro-1,2 -difluoroethane is between 36 and 106 at 50 microgr/L, and between 29 and 90 at 5 microgr/L.
Executive summary:

The reported information derives by the Existing Chemicals Survey Program Conducted by the Japanese Government.

No exhaustive description of the procedure is provided but the study was conducted under GLP and it is to OECD 305 C "Bioaccumulation: Test for the Degree of Bioconcentration in Fish".

The BCF of 1,1,2,2 -tetrachloro-1,2 -difluoroethane was derived at two different concentrations.

According to the results, at 50 microgr/L the BCF is between 36 and 106, and at 5 microgr/L is between 29 and 90.