Tetrachloro-1,2-difluoroethane

Repeated dose toxicity: oral

Administrative data

Endpoint:

repeated dose toxicity: oral

Remarks:

other: not specified

Type of information:

other: discussion based on literature data

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE

Author:

American Conference of Industrial Hygienists (ACGIH)

Year:

2008

Bibliographic source:

1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication

Reference 2

Reference Type:

publication

Title:

Renal toxicity studies of selected halogenated ethanes administered by gavage to F344/N rats.

Author:

Bucher JR

Year:

1996

Bibliographic source:

NTP Toxicology Program, Toxicology Report Series 45, NIH Pub 96-3935. Online at: http://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox045.pdf

Reference 3

Reference Type:

publication

Title:

Toxicity of the tetrachlorodifluoroethanes.

Author:

Greenberg LA & Lester D

Year:

1950

Bibliographic source:

Arch. Ind. Hyg. Occup. Med 2(3): 345-347

Reference 4

Reference Type:

publication

Title:

Fluorocarbon toxicity and biological action.

Author:

Clayton J W

Year:

1967

Bibliographic source:

Fluorine Chem Rev1:197-252

Materials and methods

Principles of method if other than guideline:

Discussion on literature data of subacute toxicty by oral route.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1,1,2,2 -tetrachloro-1,2 –difluoroethane

IUPAC Name:

1,1,2,2 -tetrachloro-1,2 –difluoroethane

Constituent 2

Reference substance name:

Tetrachloro-1,2-difluoroethane

EC Number:

200-935-6

EC Name:

Tetrachloro-1,2-difluoroethane

Cas Number:

76-12-0

Molecular formula:

C2Cl4F2

IUPAC Name:

1,1,2,2-tetrachloro-1,2-difluoroethane

Test material form:

other: no data

Details on test material:

Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112

Test animals

Species:

other: Rat, Mouse, Guinea pig, Rabbit

Results and discussion

Effect levels

Dose descriptor:

NOEL

Effect level:

125 mg/kg bw/day (nominal)

Based on:

test mat.

Sex:

not specified

Target system / organ toxicity

Critical effects observed:

not specified

Applicant's summary and conclusion

Executive summary:

The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection. ACGIH sheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondary source of information.

The results of several repeted dose toxicity studies are reported.

According to the reference, the NOEL of 125 mg/kg bw is derived from the 21 -day repeated dose toxicity study on rats.

1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the classification criteria for hazard classes related to repeated dose exposure by oral route according to Regulation (EC) No. 1272/2008.