Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

Worker

  Effect Route DNEL Dose Descriptor Modified Dose Descriptor and Assessment Factors
Acute Exposure Systemic Dermal (a)    
Inhalation (a)    
Local Dermal (a)    
Inhalation (a)    
Long-Term Exposure Systemic Dermal (a)    
Inhalation (a)    
Local Dermal (b)    
Inhalation 2.9 mg/m3/8h [corrected THC] 17.2 mg/m3/day (predicted NOAEC based on mild upper respiratory tract irritation) Dose descriptor was modified to correct starting point of 8.64 mg/m3/8h by adjustment for duration of exposure and level of activity. Then AF of 3 was applied for intraspecies and remaining differences.

a) No hazard identified for this route (data available)

b) No-threshold effect and/or no dose-response information available

General Population - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard via oral route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

General Population

 

Effect

Route

DNEL

Dose Descriptor

Modified Dose Descriptor and Assessment Factors

Acute Exposure

Systemic

 

Dermal

(a)

 

 

Inhalation

(a)

 

 

Oral

(a)

 

 

Local

Dermal

(a)

 

 

Inhalation

(a)

 

 

Long-Term Exposure

Systemic

Dermal

(a)

 

 

Inhalation

(a)

 

 

Oral

(a)

 

 

Local

Dermal

(b)

 

 

Inhalation

0.6 mg/m3/24h

17.2 mg/m3/day (predicted NOAEC based on mild upper respiratory tract irritation)

Dose descriptor was modified to correct starting point of 3.1 mg/m3/24h by adjustment for duration of exposure. Then AF of 5 was applied for intraspecies and remaining differences

a) No hazard identified for this route (data available)

b) No-threshold effect and/or no dose-response information available