Registration Dossier
Registration Dossier
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EC number: 310-079-6 | CAS number: 102242-48-8 The complex residue resulting from the vacuum distillation of C6-24 and C6-24 unsatd. fatty alcohols which is derived from hydrogenation of C6-24 and C6-24 unsatd. fatty acids methyl esters. It consists predominantly of satd. and unsatd. fatty alcohols having carbon numbers greater than C18, dimerization products, and long chain esters having carbon numbers greater than C32 and boils at > 250°C (482°F) at 10 torr.
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The test item was tested for sensitising potential according to the Buehler Testing Method, as described in the OECD TG 406 (Henkel R9300244). The treatment group comprised 20 and the control group 10 female Guinea pigs; an additional group of 5 animals was used for determination of the maximal non-irritating concentration suitable for challenge.
According to preliminary and dose finding tests, the concentration of test item for induction was set at 50% in oleum arachidis DAB 10 whereas it was 20% for the first challenge, and 10% for the rechallenge. After triple (once a week) epicutaneous application (occlusive/6 h), the first challenge (occlusive/6 h) was performed after 14 days and was followed by a rechallenge (occlusive/6 h) after 21 days following induction. Following first challenge, up to 80% of the animals of the treatment group and up to 70% of the animals of the control group showed weak to moderate skin reactions. Following rechallenge, up to 20% of the animals of the treatment group and up to 30% of the animals of the control group showed almost weak skin reactions. Since the incidence of skin reactions following challenge and rechallenge was within the same range for both, the control and the treatment group, the present test gives no indication of a sensitising potential for the test item.
Migrated from Short description of key information:
A Buehler Test conducted according to the OECD TG 406 is available (Henkel R 9300244, 1993); the test gave no indication of a sensitising potential for the test item.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No data available
Justification for classification or non-classification
According to the results of a Buehler test, "Alcohols, C6-C24 and C6-C24 unsat., distn residues"(CAS 102242-48-8) is not expected to be sensitising and thus, neither classification according to the EU Directive 67/548/EEC nor classification according to the EU CLP Regulation (EC) No. 1272/2008 is needed.
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