Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-915-0 | CAS number: 2280-49-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study conducted according to accepted scientific criteria
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- 15 male rats per dose were dosed by gavage. Symptoms and deaths were recorded.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide
- EC Number:
- 218-915-0
- EC Name:
- N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide
- Cas Number:
- 2280-49-1
- Molecular formula:
- C13H10Cl3NO2S2
- IUPAC Name:
- N-phenyl-N-[(trichloromethyl)sulfanyl]benzenesulfonamide
- Test material form:
- other: solid
- Details on test material:
- no data on purity; the compound tested was 98% N-Phenyi-N-[(trichloromethyl)thio]benzenesulphonamide and 2% magnesium carbonate.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aceton:oil 1:10
- Doses:
- 100, 250, 500, 1000, 2500 g/kg bw
- No. of animals per sex per dose:
- 15 males per group
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Dose level; No of deaths/ no of animals with symptoms/no of deaths.
100; 0/0/15
250; 0/15/15; Animals were free of symptoms on day 2
500;0/15/15; Animals were free of symptoms on day 2
1000; 0/15/15; Animals were free of symptoms on day 4
2500; 0/15/15; Animals were free of symptoms on day 4
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
No animal died even at the highest dose 2500 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
