Registration Dossier
Registration Dossier
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EC number: 218-915-0 | CAS number: 2280-49-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: highest dose tested: 500 mg/kg
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 5 male rats were dosed with a single dose of 500 mg/kg (25% solution; vehicle oil/acetone 10/1) for 7 days
- GLP compliance:
- no
- Test type:
- other: single dose experiment
Test material
- Reference substance name:
- N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide
- EC Number:
- 218-915-0
- EC Name:
- N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide
- Cas Number:
- 2280-49-1
- Molecular formula:
- C13H10Cl3NO2S2
- IUPAC Name:
- N-phenyl-N-[(trichloromethyl)sulfanyl]benzenesulfonamide
- Test material form:
- other: solid
- Details on test material:
- no data on purity; the compound tested was 98% N-Phenyi-N-[(trichloromethyl)thio]benzenesulphonamide and 2% magnesium carbonate.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Type of coverage:
- other: open; rats weared a dog-collar
- Vehicle:
- other: oil acetone 10:1
- Duration of exposure:
- 7 days
- Doses:
- 500 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- discriminating dose
- Effect level:
- >= 500 mg/kg bw
Any other information on results incl. tables
No symptoms were observed; discriminating does 500 mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Executive summary:
No symptoms were observed in 5 rabbits at 500 mg/kg, the only dose investigated.
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