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EC number: 208-063-8 | CAS number: 507-09-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Thioacetic acid
- EC Number:
- 208-063-8
- EC Name:
- Thioacetic acid
- Cas Number:
- 507-09-5
- Molecular formula:
- C2H4OS
- IUPAC Name:
- ethanethioic S-acid
- Test material form:
- other: liquidl
- Details on test material:
- - Name of test material (as cited in study report): Thioacetic acid
- batch AOGHJU,
- purity 99.58%.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa Crédo, 69210 L'Arbresle, France.
- Age at study initiation: approximately 8 weeks old
- Weight at study initiation: 269 ± 3 g for the males and 229 ± 6 g for the females
- Fasting period before study: no
- Housing: in polycarbonate cages (48 cm x 27 cm x 20 cm). Each cage contained one to seven animals of the same sex during the acclimatization period. During the treatment period, the animalswere housed individually
- Diet/ A04 C pelleted diet ad libitum
- Water: Drinking water filtered by a FG Millipore membrane (0.22 micron) was provided ad libitum.
- Acclimation period: at !east 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2
- Humidity (%): 30 to 70
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Clinical signs, mortality and body weight gain were checked for a period of 14 days following the single application of the test substance. All animals were subjected to necropsy.
- Statistics:
- None
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Mortality:
- No death occurred at 2000 mg/kg.
- Clinical signs:
- other: The general behaviour of the animals were not affected by treatment with the test substance. No cutaneous reactions were observed.
- Gross pathology:
- No apparent abnormalities were observed at necropsy in all the animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD0 of THIOACETIC ACID is equal to or higher than 2000 mg/kg in rats. No signs of toxicity were observed at this dose.
- Executive summary:
The acute dermal toxicity of THIOACETIC ACID was evaluated in rats according to OECD (No. 402, 24th February 1987) and EC (92/69/EEC, B.3, 31 st July 1992) guidelines. The study was conducted in compliance with the principles of Good Laboratory Practice Regulations. The test substance was applied to the skin of one group of ten Sprague-Dawley rats (five males and five females). The application was performed with the undiluted test substance at the dose of 2000 mg/kg, taking into consideration that its specific gravity was 1.064. The test site was then covered by a semi-occlusive dressing for 24 hours. Clinical signs, mortality and body weight gain were checked for a period of 14 days following the single application of the test substance.All animals were subjected to necropsy.No death occurred at 2000 mg/kg. The general behaviour and overall body weight gain of the animals were not affected by treatment with the test substance. No cutaneous reactions were observed.No apparent abnormalities were observed at necropsy in all the animals.Under these experimental conditions, the dermal LD0 of THIOACETIC ACID is equal to or higher than 2000 mg/kg in rats. No signs of toxicity were observed at this dose.
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