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EC number: 208-063-8 | CAS number: 507-09-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Since the test substance showed severe irritant properties in the first rabbit, the study was considered complete and the test substance was not evaluated in other animals.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Thioacetic acid
- EC Number:
- 208-063-8
- EC Name:
- Thioacetic acid
- Cas Number:
- 507-09-5
- Molecular formula:
- C2H4OS
- IUPAC Name:
- ethanethioic S-acid
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Thioacetic acid
- batch AOGHJU
- purity 99.58%.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Elevage Cunicole de Val de Selle, 80160 Prouzel, France.
- Age at study initiation: no data
- Weight at study initiation: 2.6 kg
- Housing: housed individually in polystyrene cages
- Diet: 112 C pelleted diet, ad libitum
- Water: filtered by a F.G. Miilipore membrane (0.22 micron) ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 3
- Humidity (%): 30 to 70
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12 h/12 h
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Amount applied: 0.1 ml
- Duration of treatment / exposure:
- Not rinsed
- Observation period (in vivo):
- up to 72 hours
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- As possible irritant effects were anticipated, a first assay was conducted in one male New Zealand White rabbit. Since the test substance showed severe irritant properties in this first assay, the study was considered complete and the test substance was not evaluated in other animals. A single dose of 0.1 ml of the undiluted test substance was instilled into the left conjunctival sac. The right eye served as control. The eyes were not rinsed after administration of the test substance. Ocular reactions were observed approximately 1 hour, 24, 48 and 72 hours after the administration. The mean values of the scores for chemosis and corneal opacity were calculated.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24+48+72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- after 3 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24+48+72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- after 3 days
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Remarks on result:
- other: the scoring of iritis was masked by this important corneal opacity
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Remarks on result:
- other: Scoring masked by a whitish colouration of the conjunctivae
- Irritant / corrosive response data:
- Slight or moderate conjunctival reactions (slight or moderate chemosis, whitish coloration of the conjunctivae and clear to whitish purulent discharge) were observed between day 1 and day 4. A moderate corneal opacity was recorded between day 1 and day 4; the scoring of iritis was masked by this important corneal opacity. In the view of these ocular reactions, the animal was killed on day 4 for ethical reasons. Mean scores calculated over 24, 48 and 72 hours were 3.0 for chemosis and 3.0 for corneal opacity. Other scores were not calculable.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- THIOACETIC ACID is severely irritant when administered by ocular route to rabbits.
- Executive summary:
The potential of THIOACETIC ACID to induce ocular irritation was evaluatedin rabbits according to OECD (No. 405, 24th February 1987) and EC (92/69/EEC, B.5, 31 st July1992) guidelines. The study was conducted in compliance with the principles of Good Laboratory Practice Regulations. As possible irritant effects were anticipated, a first assay was conducted in one male New Zealand White rabbit. Since the test substance showed severe irritant properties in this first assay, the study was considered complete and the test substance was not evaluated in other animals. A single dose of 0.1 ml of the undiluted test substance was instilled into the left conjunctival sac. The right eye served as control. The eyes were not rinsed after administration of the test substance. Ocular reactions were observed approximately 1 hour, 24, 48 and 72 hours after the administration. The mean values of the scores for chemosis and corneal opacity were calculated. Slight or moderate conjunctival reactions (slight or moderate chemosis, whitish coloration of the conjunctivae and clear to whitish purulent discharge) were observed between day 1 and day 4. A moderate corneal opacity was recorded between day 1 and day 4; the scoring of iritis was masked by this important corneal opacity. In the view of these ocular reactions, the animal was killed on day 4 for ethical reasons. Mean scores calculated over 24, 48 and 72 hours were 3.0 for chemosis and 3.0 for corneal opacity. Other scores were not calculable. THIOACETIC ACID is severely irritant when administered by ocular route to rabbits.
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