Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-063-8 | CAS number: 507-09-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The potential of THIOACETIC ACID, to induce delayed contact hypersensitivity following intradermal injection and cutaneous application was evaluated in guinea-pigs according to the maximization method of Magnusson and Kligman and O.E.C.D. (No. 406, 12th May 1981) (Clouzeau, 1994). The study was conducted in compliance with the Principles of Good Laboratory Practice Regulations.
Thirty guinea-pigs (15 males and 15 females) were allocated to 2 groups: a control group 1 (5 males and 5 females) and a treated group 2 (10 males and 10 females).
The sensitization potential of the test substance was evaluated after a 10-day induction periodduring which time the animals were treated with the vehicle (control group) or the test substance(treated group). On day 1, in presence of Freund's complete adjuvant, 0.1 ml of the test substance at a concentration of 1% in the vehicle was administered by intradermal route. On day 8, 0.5 ml of the test substance at a concentration of 10% in the vehicle was applied by cutaneous route during 48 hours by means of an occlusive dressing. After a period of 12 days without treatment, a challenge cutaneous application of 0.5 ml of the vehicle (left flank) and 0.5 ml of the test substance at a concentration of 10% in the vehicle (right flank) were administered to ail animals.
The test substance and the vehicle were prepared on a dry compress then were applied to the skin and held in place for 24 hours by means of an occlusive dressing. Cutaneous reactions on the challenge application sites were then evaluated 24 and 48 hours after removal of the dressing.
After the final scoring period, the animals were sacrificed and cutaneous samples were taken from the challenge application sites from ail the animals. No histological examination was performed on the cutaneous samples.
The sensitivity of the guinea-pigs in the laboratory experimental conditions were checked in a recent study with a positive sensitizer: Dinitro 2.4 Chlorobenzene. During induction period the test substance was applied at 0.05% (day 1) and 0.5% (day 8) concentrations. At cutaneous challenge application, 0.1% and 0.5% were tested on both flanks.
No clinical signs and no deaths were noted during the study.
Sensitization skin reactions characterised by a well-defined and a moderate to severe erythema were observed after 24 hours on the right flank of 14/20 treated animals. No oedema was observed.
Inconclusive evidence of sensitization skin reactions (very slight erythema, score of 1) were noted in 6/20 treated animals.
After 48 hours, intensity of erythema reversed slightly.
A dryness of the skin was noted after 48 hours in 19/20 treated animals.No oedema was observed.
The guinea-pigs which were used showed a satisfactory sensitization response in 100% animals using a positive sensitizer.
THIOACETIC ACID, induced positive skin sensitization cutaneous reactions in 14/20 (60%) guinea-pigs.
Migrated from Short description of key information:
THIOACETIC ACID induced delayed contact hypersensitivity in guinea-pigs.
Justification for selection of skin sensitisation endpoint:
Key study
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Skin sensitization:
In a GPMT assay, thioacetic acid induced skin sensitiziation in 60% of the guinea pigs with an induction concentration of 1%. On the basis of this study and in accordance with Regulation (EC) No 1272/2008, thioacetic acid was classified as skin sensitizer category 1A (Hazard statement H317; May cause an allergic skin reaction) and in accordance with Annex VI of Commission Directive 2001/59/EC, thioacetic acid was classified as irritant with the symbol Xi and the phrase R43 ‘May cause sensitisation by skin contact’.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)