Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Description of key information

An experimental study was not performed because measurements should be made on ionizable substances only in their non-ionized form (test guideline A.8). The calculation was performed using KOWWIN v.1.68 (U.S. Environmental Protection Agency) on a personal computer running Windows XP. The structure is entered into KOWWIN by SMILES notations. KOWWIN uses a "fragment constant" methodology to predict log KOW. For a complete description of KOWWIN's methodology see W.M. Meylan and P.H. Howard, "Atom/Fragment Contribution Method for Estimating Octanol-Water Partition Coefficients", Journal of Pharmaceutical Sciences, Vol. 84, No. 1, January 1995, p. 83 - 91.

Key value for chemical safety assessment

Log Kow (Log Pow):

Additional information

The calculation can be considered reliable and suitable for use as the key study for this endpoint.