Registration Dossier
Registration Dossier
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EC number: 219-847-4 | CAS number: 2550-26-7
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Publication in Japanese, no details available
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The environment of the skin
- Author:
- Ishihara M
- Year:
- 1 978
- Bibliographic source:
- Journal of the Medical Society of Toho University, Japan 25(5/6), 750-765
- Reference Type:
- publication
- Title:
- Some problems with patch tests using fragrance materials
- Author:
- Ishihara M, Itoh M, Hosono K
- Year:
- 1 978
- Bibliographic source:
- Skin Research 23(6), 806-817
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The substance was applied to human skin with patches at concentrations of 2% and 5%.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-phenylbutan-2-one
- EC Number:
- 219-847-4
- EC Name:
- 4-phenylbutan-2-one
- Cas Number:
- 2550-26-7
- Molecular formula:
- C10H12O
- IUPAC Name:
- 4-phenylbutan-2-one
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- no data
- Clinical history:
- no data
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- No preexisting skin sensitization was observed in dermatologic patients.
NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 0
- Number of subjects with negative reactions: 41
- Number of subjects with equivocal reactions: 0
- Number of subjects with irritating reactions: 0
Applicant's summary and conclusion
- Conclusions:
- The substance was not sensitising to human skin in a patch test.
- Executive summary:
The substance was not sensitising to human skin in vivo at concentrations of 2% and 5%.
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