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EC number: 219-847-4 | CAS number: 2550-26-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1980-02-27 to 1980-05-28
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: similar to OECD Guideline 401 (Acute Oral Toxicity)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-phenylbutan-2-one
- EC Number:
- 219-847-4
- EC Name:
- 4-phenylbutan-2-one
- Cas Number:
- 2550-26-7
- Molecular formula:
- C10H12O
- IUPAC Name:
- 4-phenylbutan-2-one
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Benzyl acetone
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Acce Animals
- Age at study initiation: 8 weeks old
- Weight at study initiation: 160-235 g
- Fasting period before study: 16-20 hours
- Housing: 5/cage
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-21
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 2.47, 3.12, 3.95, 5.0, 6.33 g/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 3-4 hours after dosing and once daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- The LD50 was calculated according to the method of Litchfield JTJ & Wilcoxon F, JPET 96-99, 1949.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 300 - 4 450
- Mortality:
- In 2.47 g/kg bw dose group, two animals died on day one. In 3.12 g/kg bw dose group, one animal died 3-4 hours post dose, three animals on day one and one animal on day 6. In 3.95 g/kg bw dose group, two animals died 3-4 hours post dose, five on day one and one on day 6. In 5.0 g/kg bw dose group, four animals died 3-4 hours post dose and three on day one. In 6.33 g/kg bw dose group, six animals died 3-4 hours post dose and three on day one.
- Clinical signs:
- other: Lethargy, piloerection and ptosis were observed in all dose groups. Chromorhinorrhea was observed in all dose groups except the high dose group. Prostration or coma were generally noted prior to death.
- Gross pathology:
- At necropsy congested or hemorrhagic lungs, emphysema, dilated hearts and gastrointestinal distentions were noted in most deaths. Survivors were normal.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance was acutely non toxic to rats in an acute oral toxicity test with an LD50 value of 3200 mg/kg bw. The substance is not classified according to CLP.
- Executive summary:
Ten healthy male Wistar rats with initial body weights between 168-226 grams per dose level were used. Animals were fasted 16-20 hours prior to dosing. Otherwise, food and water was available freely. Observations for mortality and/or systemic effects were made 3-4 hours post dose and daily thereafter for 14 days. Surviving animals were sacrificed on day 14. A gross necropsy was conducted on all animals. The LD50 was calculated according to the method of Litchfield and Wilcoxon, 1949, is 3.2 (2.30-4.45) g/kg. In 2.47 g/kg bw dose group, two animals, in 3.12 g/kg bw dose group 5 animals, in 3.95 g/kg bw dose group 8 animals, in 5.0 g/kg bw dose group 7 animals and in 6.33 g/kg bw dose group 9 animals died within the observation period. Prostration or coma were generally noted prior to death.
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