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Toxicological information

Endpoint summary

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Administrative data

Key value for chemical safety assessment

Additional information

Three tests in vitro (Ames, HPRT and MNT) according to data requirements are negative. Further testing on the genetic toxicity of 4 -phenylbutan-2 -one is not required.

Justification for selection of genetic toxicity endpoint

GLP and guideline study performed in mammalian cells to detect the activity of clastogenic and aneugenic chemicals

Short description of key information:

Ames test: negative (±S9 mix)

HPRT test: negative (±S9 mix)

MNT test: negative (± S9 mix)

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on the above stated assessments on genotoxicity the test substance 4-phenylbutan-2 -one is not considered to be genotoxic and does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and according to CLP (Regulation (EC) No 1272/2008 of the European Parliament and of the Council) as implementation of UN-GHS in the EU.