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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

The 48 h EL50 of the read-across substance bisamide (UVCB) to Daphnia magna for immobilisation was > 10 mg/L (nominal loading rate). The no observed effect loading rate (NOELR) was 10 mg/L (nominal). No toxicity was observed at the limit of solubility of the test substance.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
10 mg/L

Marine water invertebrates

Marine water invertebrates
Effect concentration:
10 mg/L

Additional information

A study was performed to assess the acute toxicity of the read-across substance bisamide (UVCB) to Daphnia magna according to OECD Guideline 202 and EU Method C.2 in compliance with GLP. A group of twenty Daphnia, less than 24 h old, was exposed to a WAF of the test substance prepared from an aqueous mixture with an initial nominal loading rate of 10 mg/L (direct addition of the test substance to the diluent media). To aid dissolution, the aqueous mixture was stirred for approximately 24 h in the dark, then left to stand for another 24 h in the dark before the aqueous phase was removed and filtered (0.2 μm pore size cellulose nitrate). The resultant WAF was used in the test. Concentrations were not verified analytically because of the high insolubility of the substance; results were therefore expressed as nominal loading rates. Observations of theDaphniawere made after 24 and 48 h. No immobilisation or sub-lethal effects were noted. Under the test conditions, the 48 h EL50 of the test substance toDaphnia magnafor immobilisation was >10 mg/L (nominal loading rate). The no observed effect loading rate (NOELR) was 10 mg/L (nominal). No toxicity was observed at the limit of solubility of the test substance.