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Ecotoxicological information

Long-term toxicity to fish

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Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to fish, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
for read across
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Long term toxicity of test material on fish
GLP compliance:
not specified
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
14 d
Reference substance (positive control):
not specified
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
440 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
250 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
not specified
Conclusions:
The test material is not likely to be toxic to fish in chronic study . The effect concentration is in the range of 250-440 mg/l for 14 days
Executive summary:

Data available for the functionally similar read across chemicals has been reviewed to determine the long term toxicity of fish of the test chemical .The studies are as mentioned below:

For a functionally similar read across substance, long term toxicity test of test material was performed for 14 days , The LC 50 for test material observed after 14 days was 250 mg/l and NOEC was noted at 35 mg/l.Based on the above effect concentration it can be considered that test material has no long term toxicity effect on fish , and can be considered to be not classified as per CLP criteria.

For another functionally similar read across substance , long term toxicity test of test material was performed for 14 days , The LC 50 for test material observed after 14 days was 440 mg/l and NOEC was noted at 74 mg/l.Based on the above effect concentration it can be considered that test material has no long term toxicity effect on fish , and can be considered to be not classified as per CLP criteria.

Description of key information

Long-term toxicity to fish:

Data available for the functionally similar read across chemicals has been reviewed to determine the long term toxicity of fish of the test chemical .The studies are as mentioned below:

For a functionally similar read across substance, long term toxicity test of test material was performed for 14 days , The LC 50 for test material observed after 14 days was 250 mg/l and NOEC was noted at 35 mg/l.Based on the above effect concentration it can be considered that test material has no long term toxicity effect on fish , and can be considered to be not classified as per CLP criteria.

For another functionally similar read across substance , long term toxicity test of test material was performed for 14 days , The LC 50 for test material observed after 14 days was 440 mg/l and NOEC was noted at 74 mg/l.Based on the above effect concentration it can be considered that test material has no long term toxicity effect on fish , and can be considered to be not classified as per CLP criteria.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
250 mg/L

Additional information

Long-term toxicity to fish:

Data available for the functionally similar read across chemicals has been reviewed to determine the long term toxicity of fish of the test chemical .The studies are as mentioned below:

For a functionally similar read across substance, long term toxicity test of test material was performed for 14 days , The LC 50 for test material observed after 14 days was 250 mg/l and NOEC was noted at 35 mg/l.Based on the above effect concentration it can be considered that test material has no long term toxicity effect on fish , and can be considered to be not classified as per CLP criteria.

For another functionally similar read across substance , long term toxicity test of test material was performed for 14 days , The LC 50 for test material observed after 14 days was 440 mg/l and NOEC was noted at 74 mg/l.Based on the above effect concentration it can be considered that test material has no long term toxicity effect on fish , and can be considered to be not classified as per CLP criteria.