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Ecotoxicological information

Toxicity to microorganisms

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Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
of read across substance
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two toxicity study of microorganism for the test chemical :
The effect of test material on growth of Pseudomonas fluorescens
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: 1)Pseudomonas fluorescens 2) Activated sludge
Test type:
static
Water media type:
freshwater
Total exposure duration:
24 h
Reference substance (positive control):
not specified
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
500 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Duration:
1 h
Dose descriptor:
EC50
Effect conc.:
1 600 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Validity criteria fulfilled:
not specified
Conclusions:
The test chemical is not likely to be toxic to microorganism atleast in the concentartion range of 500-1600 mg/l
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

In a study effect of test material was observed on microorganism . The EC0 after 48 h for test organism Pseudomonas fluorescens was observed to be 500 mg/l.

In another study , The effect of test material was tested on activated sludge . The EC50 observed after 1 h for activated sludge was 1600 mg/l.

The test chemical  is not likely to be toxic to microorganism atleast in the concentartion range of 500-1600 mg/l

Description of key information

Toxicity to microorganisms:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

In a study effect of test material was observed on microorganism . The EC0 after 48 h for test organism Pseudomonas fluorescens was observed to be 500 mg/l.

In another study , The effect of test material was tested on activated sludge . The EC50 observed after 1 h for activated sludge was 1600 mg/l.

The test chemical  is not likely to be toxic to microorganism atleast in the concentartion range of 500-1600 mg/l

Key value for chemical safety assessment

EC50 for microorganisms:
500 mg/L

Additional information

Toxicity to microorganisms:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

In a study effect of test material was observed on microorganism . The EC0 after 48 h for test organism Pseudomonas fluorescens was observed to be 500 mg/l.

In another study , The effect of test material was tested on activated sludge . The EC50 observed after 1 h for activated sludge was 1600 mg/l.

The test chemical  is not likely to be toxic to microorganism atleast in the concentartion range of 500-1600 mg/l