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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP-Study, Limit Test, Lack of documentation.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
GLP compliance:
no
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(4-aminophenyl)-6-methylbenzothiazole-7-sulphonic acid
EC Number:
204-979-7
EC Name:
2-(4-aminophenyl)-6-methylbenzothiazole-7-sulphonic acid
Cas Number:
130-17-6
Molecular formula:
C14H12N2O3S2
IUPAC Name:
2-(4-aminophenyl)-6-methyl-1,3-benzothiazole-7-sulfonic acid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Doses:
5000 mg/kg BW
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
Within a 14 days period after application only one male animal died. In the control group no mortality was observed.
Clinical signs:
other: Scrubby coat, convulsed bearing, pale extremities, muscle tremor, lethargy, ataxia
Gross pathology:
Died animal:
Moderate hyperemia and moderate hemorrhagic edema of the lungs, slight hyperemia of the liver and slight congestion of the gastric mucosa.
Killed animals:
low to moderate hyperemia of the lungs and moderate hyperemia of the liver.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU