Registration Dossier
Registration Dossier
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EC number: 622-542-2 | CAS number: 3891-98-3
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- Farnesane
- Type of composition:
- legal entity composition of the substance
- State / form:
- liquid
- Reference substance:
- Farnesane
- Name:
- Farnesane
- Type of composition:
- boundary composition of the substance
- State / form:
- liquid
- Reference substance:
- Farnesane
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence
An OECD 308 sediment and freshwater simulation study and an OECD 307 soil simulation study has been completed on this substance. In Overlying water a maximum DT50 of 0.302 days was recorded, in combined soil and sediment a maximum DT50 of 1.45 days was reported and in soil a maximum DT50 of 9.39 days was reported. It has therefore been shown that this substance is not persistent in water, sediment and soil under environmentally relevant conditions.
Bioaccumulation
The BIOCONCENTRATION FACTOR (LOG BCF) value of the test item were determined as: 3.0
The mean BCF was determined as 1000 with a min of 158 and a max of 2138. Only one model out of the 9 within the applicability domain predicted a BCF >2000. Using the consensus approach, the substance is considered to have a BCF of 1000 and to be below the B criterion used in PBT assessment of 2000 L/Kg.
Toxicity
In a long-term fish, daphniid and algae toxicity study, no toxicity was observed at the limit of water solubility (0.25 µg/L).
In a 21-day Daphnia reproduction study the NOEC was 54 μg/L with a LOEC of 77 μg/L. These measured concentrations were greater than the known water solubility of the test material. There was no evidence of toxicity at the limit of water solubility.
Farnesane is not classified as carcinogenic, mutagenic or toxic to reproduction.
There is no evidence to indicate that farnesane should be classified for repeat dose toxicity endpoints. The dossier includes a testing proposal for a sub-chronic oral toxicity study.
Referenceopen allclose all
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