Registration Dossier
Registration Dossier
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EC number: 204-436-4 | CAS number: 120-93-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- The test substance was applied as powder (0.1 g) into the right eyes of 2 rabbits, the left eye was treated with physiological saline solution for comparison. The observation period was 10 days.
- GLP compliance:
- no
- Remarks:
- pre-GLP
Test material
- Reference substance name:
- 2-imidazolidone
- EC Number:
- 204-436-4
- EC Name:
- 2-imidazolidone
- Cas Number:
- 120-93-4
- Molecular formula:
- C3H6N2O
- IUPAC Name:
- 2-imidazolidone
- Test material form:
- solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: saline-treated eye of same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 g - Duration of treatment / exposure:
- single application, no washing was performed
- Observation period (in vivo):
- 10 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: no
Results and discussion
In vivo
Results
- Irritation parameter:
- other: observations regarding eye irritation
- Basis:
- other: observations in individual animals
- Remarks on result:
- other: Findings: on day of treatment: redness and discharge in 2/2; day 2: redness in 1/2, discharge and slight opacity in 1/2; day 3: redness and chemosis in 1/2; day 6: complete reversibility
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
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