Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Classification & Labelling & PBT assessment

PBT assessment

Administrative data

PBT assessment: overall result

PBT status:
the substance is not PBT / vPvB

Classification of piperazine adipate for effects in the environment

In determining the classification appropriate to piperazine adipate, it is necessary to consider all available evidence concerning its persistence, potential to accumulate and predicted or observed environmental fate and behaviour that may present a long-term and/or delayed danger to the structure and/or functioning of aquatic ecosystems. These points are considered below.



Reliable studies are available to demonstrate that piperazine adipate is non persistent in nature and so is considered to have rapid biodegradation in the environment. In other words piperazine adipate degradation may therefore be expected to be fast. Thus it can be inferred that piperazine adipate is non persistent in character. 


Piperazine adipate is non persistent and so does not satisfy the criteria for classification as persistent (P). 


Potential to accumulate

Predicted and measured log Kow values for piperazine adipate is less than 4 (Log Kow = -0.522). The potential for piperazine adipate to bioaccumulate in the tissues of organisms that inhabit aquatic or terrestrial matrices is negligible as the BCF factor for the substance is less than 1000.  


 The calculated BCF of piperazine adipate is 3.162 dimensionless and below the threshold of 2000. 


Piperazine adipate does not satisfy the criterion for classification as bioaccumulative (B).


The toxicity values of fish, invertebrates and algae are LC50 = 134.66 mg/L, EC50 = 201.06 mg/L are EC50 = 119.68 mg/L, respectively. The toxicity values of the three trophic levels do not fall in the criteria for classification (CLP regulation) of this chemical for aquatic toxicity

So, piperazine adipate does not satisfy the environmental effects criterion for classification as toxic (T).


Thus it can be inferred that piperazine adipate is not a PBT substance