Registration Dossier

Administrative data

Description of key information

GPMT (OECD 406): not sensitising

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The skin sensitization potential of the whole range of alcohol ethoxylates (AEs) was evaluated by the majority in the guinea pig maximisation test according to the Magnusson Kligman and in the non-adjuvant Buehler test protocol in guinea pigs.

In summary, all of the six studies conducted with the Cas-No. 71060-57-6, 68439-50-9, 68551-12-2, 66455-14-9, 68131-39-5 and 68439-49-6 showed that the AEs have no skin sensitizing potential. Hence, no classification is warranted.

Skin sensitization tests conducted with AEs showed all a negative result.

Justification for selection of skin sensitisation endpoint:
Reliable OECD Guideline study was selected

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Classifcation criteria for skin sensitisation according to Regulation (EC) No. 1272/2008 are not fulfilled. No data available for respiratory sensitisation.