Registration Dossier
Registration Dossier
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EC number: 251-118-6 | CAS number: 32588-76-4
Endpoint summary
Administrative data
Description of key information
Additional information
Several factors, as described by REACH Guidance Chapter R11, beginning on page 42 and Comber et al. (2005)*, indicate EBTBP has low potential for bioaccumulation. Its molecular weight, 959.2, is > 700. It’s measured solubility in octanol, 0.45-0.6 mg l-1, is 1.9 and <0.002 * MW. According to REACH Guidance, when the solubility in octanol is less than this value, it can be assumed that the compound has only a limited potential to establish high body burdens and to bioaccumulate, and that if bioaccumulation were to occur, it would be unlikely to rise to levels in biota that would cause significant effects. EBTBP’s estimated fish bioconcentration factor, 9.3, is similar to the measured value derived from a study conducted at concentrations higher than its water solubility. Repeated dose studies in two mammalian species (28 -d rat, 90 -d rat, rat prenatal developmental, rabbit prenatal devleopmental) provide NOEL’s of 1,000 mg/kg/d. A repeated dose excretion and distribution study in rats did not indicate accumulation of the radiolabel. Thus, EBTBP is not considered bioaccumulative or toxic in mammals.
*Comber et al. 2005. Discussion paper for the TC NES subgroup on PBTs.
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