3,5-xylidine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Xylidine, BUA Stoffbericht 161

Year:

1994

Bibliographic source:

BUA, Beratergremium für umweltrelevante Altstoffe (BUA) der Gesellschaft Deutscher Chemiker, S.Hirzel Verlag 1995

Reference 2

Reference Type:

publication

Title:

Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqeous solutions.

Author:

Vernot et al.

Year:

1977

Bibliographic source:

Toxicol. Appl. Pharmacol. 42, 417-423 (1977)

Materials and methods

Test guideline

Guideline:

other: no data

GLP compliance:

not specified

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

3,5-xylidine

EC Number:

203-607-0

EC Name:

3,5-xylidine

Cas Number:

108-69-0

Molecular formula:

C8H11N

IUPAC Name:

3,5-dimethylaniline

Test material form:

liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

710 mg/kg bw

Based on:

test mat.

95% CL:

>= 470 - <= 1 070

Clinical signs:

other:

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Remarks:

EU GHS

Conclusions:

The oral LD50 in rat was described as 710 mg/kg.

Executive summary:

The test item was assessed in an standard acute toxicity test in rats following national stndard methods. The oral LD50 in rats was determined to be 710 mg/kg.