Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1990
Reference Type:
secondary source
Title:
Xylidine, BUA Stoffbericht 161
Year:
1994
Bibliographic source:
BUA, Beratergremium für umweltrelevante Altstoffe (BUA) der Gesellschaft Deutscher Chemiker, S.Hirzel Verlag 1995

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3,5-xylidine
EC Number:
203-607-0
EC Name:
3,5-xylidine
Cas Number:
108-69-0
Molecular formula:
C8H11N
IUPAC Name:
3,5-dimethylaniline

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
4 h

Results and discussion

Any other information on results incl. tables

The substance was found to be not irritating on semiocclusive application of 0,5 ml of the substance on the skin of white rabbits for 4 h.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU