Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1990
Reference Type:
secondary source
Title:
Xylidine, BUA Stoffbericht 161
Year:
1994
Bibliographic source:
BUA, Beratergremium für umweltrelevante Altstoffe (BUA) der Gesellschaft Deutscher Chemiker, S.Hirzel Verlag 1995

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Qualifier:
according to guideline
Guideline:
EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3,5-xylidine
EC Number:
203-607-0
EC Name:
3,5-xylidine
Cas Number:
108-69-0
Molecular formula:
C8H11N
IUPAC Name:
3,5-dimethylaniline
Details on test material:
Purity 98%

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)

Results and discussion

Any other information on results incl. tables

The application of 0,1 ml of 3,5 -xylidine caused only slight corneal opacity and redding. The symptoms were reversible within 7 days.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU

Categories Display